Your vaginal area can harbor bacteria and germs. You need to wash the area to make sure these bacteria and germs don’t enter your vagina when you insert the suppository. Make sure your soap is unscented, as fragrances can cause irritation. [1] X Research source

Your hands can also have germs and bacteria on them, and you don’t want to transfer any germs or bacteria into your vagina.

It’s best to lightly hold your suppository between 2 fingers. Never hold it in your palm.

Pull your legs as far back as possible, rather than just bending your knees.

Remember to use a light touch when handling the suppository, as it can easily melt in your hands.

You should not feel any pain or discomfort when you insert the suppository. If you do, stop pushing and remove your finger.

It’s unlikely that the suppository will stay stuck to your finger. If this happens, however, re-insert the suppository into your vagina. Press against the side wall of your vagina to help it stick.

You don’t need to stay lying down after you insert the suppository.

Your suppositories should look like ovals or bullets. They’re usually prepared by the pharmacist, so check with them if you have any questions.

If it’s close to your next scheduled dose, skip the dose you forgot to take.

While using vaginal progesterone, don’t wear tight pants, nylon panties, or tights. These materials don’t breathe, so they increase your risk of developing a yeast infection. [9] X Research source

Remember to change your pad every few hours. You want to keep your vaginal area as dry as possible, which will help prevent a yeast infection. If you use your suppository right before bedtime, you will experience less discharge than if you walk around after you insert it.

You might start your period while you’re using the progesterone. If this happens, continue to use sanitary pads only. Don’t use tampons.

Some progesterone suppositories can be stored at room temperature. Check the label on your medication to be sure. Don’t freeze your suppositories.

You shouldn’t take progesterone during pregnancy unless it’s prescribed as part of your fertility treatment. Progesterone can increase your risk of developing blood clots, stroke, heart attack, or breast cancer. This risk is greater if you have a personal or family history of these conditions.